Long ligands reinforce biological adhesion under shear flow
نویسنده
چکیده
In the present work the computer modelling was used to show that longer ligands allow biological cells (e.g. blood platelets) to withstand stronger flows after their adhesion to solid walls. Mechanistic model of polymer-mediated ligand-receptor adhesion between a microparticle (cell) and a flat wall was developed. Theoretical threshold between adherent and non-adherent regimes was derived analytically and approved by the simulations. These results lead to deeper understanding of numerous biophysical processes, e.g. arterial thrombosis, and to the design of new biomimetic colloid-polymer systems.
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